{"id":17804,"date":"2020-06-22T15:32:40","date_gmt":"2020-06-22T18:32:40","guid":{"rendered":"https:\/\/www.epimedsolutions.com\/publicacao\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/"},"modified":"2020-06-22T15:37:27","modified_gmt":"2020-06-22T18:37:27","slug":"impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections","status":"publish","type":"publicacao","link":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/","title":{"rendered":"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objectives:&nbsp;<\/strong>To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI).<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>Planned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) &gt; 48 h. COPD patients (n = 494) were compared to non-COPD patients (n = 2466). The diagnosis of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) was based on clinical, radiological and quantitative microbiological criteria.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>No significant difference was found in VAP (12% versus 13%, p = 0.931), or VAT incidence (13% versus 10%, p = 0.093) between COPD and non-COPD patients. Among patients with VA-LRTI, Escherichia coli and Stenotrophomonas maltophilia were significantly more frequent in COPD patients as compared with non-COPD patients. However, COPD had no significant impact on multidrug-resistant bacteria incidence. Appropriate antibiotic treatment was not significantly associated with progression from VAT to VAP among COPD patients who developed VAT, unlike non-COPD patients. Among COPD patients, patients who developed VAT or VAP had significantly longer MV duration (17 days (9-30) or 15 (8-27) versus 7 (4-12), p &lt; 0.001) and intensive care unit (ICU) length of stay (24 (17-39) or 21 (14-40) versus 12 (8-19), p &lt; 0.001) than patients without VA-LRTI. ICU mortality was also higher in COPD patients who developed VAP (44%), but not VAT(38%), as compared to no VA-LRTI (26%, p = 0.006). These worse outcomes associated with VA-LRTI were similar among non-COPD patients.<\/p>\n\n\n\n<p><strong>Conclusions:&nbsp;<\/strong>COPD had no significant impact on incidence or outcomes of patients who developed VAP or VAT.<\/p>\n\n\n\n<p><strong>Keywords:&nbsp;<\/strong>chronic obstructive pulmonary disease; intensive care; lower respiratory tract infections; mechanical ventilation; pneumonia; tracheobronchitis; ventilator-associated.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Conflict of interest statement<\/h4>\n\n\n\n<p>S.N.: MSD, Pfizer, Biom\u00e9rieux, Gilead (lecture and advisory board). A.R.: MaatPharma (advisory board). Appendix A. Other authors declare that they have no competing interests.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Figures<\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"732\" height=\"408\" src=\"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg\" alt=\"\" class=\"wp-image-17798\"\/><figcaption><strong>Figure 1<\/strong>&nbsp;Study flowchart. Data are presented as number of patients. Only first episodes of VA-LRTI were taken into account. COPD, Chronic Obstructive Pulmonary Disease; VA-LRTI, ventilator-associated lower respiratory tract infection; VAP, ventilator-associated pneumonia; VAT, ventilator-associated tracheobronchitis.<\/figcaption><\/figure>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31979375\/\">Read more on the Pubmed<\/a><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-17804","publicacao","type-publicacao","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections - Epimed Solutions<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections - Epimed Solutions\" \/>\r\n<meta property=\"og:description\" content=\"Abstract Objectives:&nbsp;To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI). Methods:&nbsp;Planned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) [&hellip;]\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/\" \/>\r\n<meta property=\"og:site_name\" content=\"Epimed Solutions\" \/>\r\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/epimed\/\" \/>\r\n<meta property=\"article:modified_time\" content=\"2020-06-22T18:37:27+00:00\" \/>\r\n<meta property=\"og:image\" content=\"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:site\" content=\"@epimed\" \/>\r\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/\",\"url\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/\",\"name\":\"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections - Epimed Solutions\",\"isPartOf\":{\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg\",\"datePublished\":\"2020-06-22T18:32:40+00:00\",\"dateModified\":\"2020-06-22T18:37:27+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#primaryimage\",\"url\":\"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg\",\"contentUrl\":\"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\/\/www.epimedsolutions.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/www.epimedsolutions.com\/en\/publication\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/#website\",\"url\":\"https:\/\/www.epimedsolutions.com\/en\/\",\"name\":\"Epimed Solutions\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.epimedsolutions.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/#organization\",\"name\":\"Epimed Solutions\",\"url\":\"https:\/\/www.epimedsolutions.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/epimedsolutions.com\/wp-content\/uploads\/2020\/04\/logo-epimed-1.png\",\"contentUrl\":\"https:\/\/epimedsolutions.com\/wp-content\/uploads\/2020\/04\/logo-epimed-1.png\",\"width\":400,\"height\":193,\"caption\":\"Epimed Solutions\"},\"image\":{\"@id\":\"https:\/\/www.epimedsolutions.com\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/epimed\/\",\"https:\/\/x.com\/epimed\",\"https:\/\/www.instagram.com\/epimedsolutions\/\",\"https:\/\/www.youtube.com\/user\/epimedsolutions\/\"]}]}<\/script>\r\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections - Epimed Solutions","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/","og_locale":"en_US","og_type":"article","og_title":"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections - Epimed Solutions","og_description":"Abstract Objectives:&nbsp;To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI). Methods:&nbsp;Planned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) [&hellip;]","og_url":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/","og_site_name":"Epimed Solutions","article_publisher":"https:\/\/www.facebook.com\/epimed\/","article_modified_time":"2020-06-22T18:37:27+00:00","og_image":[{"url":"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_site":"@epimed","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/","url":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/","name":"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections - Epimed Solutions","isPartOf":{"@id":"https:\/\/www.epimedsolutions.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#primaryimage"},"image":{"@id":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#primaryimage"},"thumbnailUrl":"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg","datePublished":"2020-06-22T18:32:40+00:00","dateModified":"2020-06-22T18:37:27+00:00","breadcrumb":{"@id":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#primaryimage","url":"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg","contentUrl":"https:\/\/www.epimedsolutions.com\/wp-content\/uploads\/2020\/06\/microorganisms-08-00165-g001-1.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.epimedsolutions.com\/en\/publication\/impact-of-chronic-obstructive-pulmonary-disease-on-incidence-microbiology-and-outcome-of-ventilator-associated-lower-respiratory-tract-infections\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/www.epimedsolutions.com\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/www.epimedsolutions.com\/en\/publication\/"},{"@type":"ListItem","position":3,"name":"Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections"}]},{"@type":"WebSite","@id":"https:\/\/www.epimedsolutions.com\/en\/#website","url":"https:\/\/www.epimedsolutions.com\/en\/","name":"Epimed Solutions","description":"","publisher":{"@id":"https:\/\/www.epimedsolutions.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.epimedsolutions.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.epimedsolutions.com\/en\/#organization","name":"Epimed Solutions","url":"https:\/\/www.epimedsolutions.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.epimedsolutions.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/epimedsolutions.com\/wp-content\/uploads\/2020\/04\/logo-epimed-1.png","contentUrl":"https:\/\/epimedsolutions.com\/wp-content\/uploads\/2020\/04\/logo-epimed-1.png","width":400,"height":193,"caption":"Epimed Solutions"},"image":{"@id":"https:\/\/www.epimedsolutions.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/epimed\/","https:\/\/x.com\/epimed","https:\/\/www.instagram.com\/epimedsolutions\/","https:\/\/www.youtube.com\/user\/epimedsolutions\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.epimedsolutions.com\/en\/wp-json\/wp\/v2\/publicacao\/17804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.epimedsolutions.com\/en\/wp-json\/wp\/v2\/publicacao"}],"about":[{"href":"https:\/\/www.epimedsolutions.com\/en\/wp-json\/wp\/v2\/types\/publicacao"}],"wp:attachment":[{"href":"https:\/\/www.epimedsolutions.com\/en\/wp-json\/wp\/v2\/media?parent=17804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}