Material Educativo

[Artigo] Chloroquine (All Populations Monograph)

Chloroquine monograph – Indications/Dosage
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Labeled

  • amebiasis
  • malaria
  • malaria prophylaxis

Off-Label, Recommended

  • coronavirus disease 2019 (COVID-19) †
  • discoid lupus erythematosus †
  • severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection †

Per the manufacturer, this drug has been shown to be active against most strains of the following microorganisms either in vitro and/or in clinical infections:

Entamoeba histolytica, Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale, Plasmodium vivax.

NOTE: The safety and effectiveness in treating clinical infections due to organisms with in vitro data only have not
been established in adequate and well-controlled clinical trials.

This drug may also have activity against the following microorganisms:

severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

NOTE: Some organisms may not have been adequately studied during clinical trials; therefore, exclusion from this
list does not necessarily negate the drug’s activity against the organism.

For the treatment of uncomplicated malaria due to susceptible strains of P.
falciparum, P. knowlesi†, P. malariae, P. ovale, and P. vivax

Oral dosage

  • Adults
    16.5 mg (10 mg base)/kg/dose [Max: 1,000 mg/dose (600 mg base/dose)] PO once, then 8.3 mg (5 mg
    base)/kg/dose [Max: 500 mg/dose (300 mg base/dose)] PO in 6 to 8 hours, then 8.3 mg (5 mg
    base)/kg/dose [Max: 500 mg/dose (300 mg base/dose)] PO once daily for 2 days.[29758] For P. vivax or
    P. ovale, give in combination with primaquine phosphate or tafenoquine. Guidelines recommend
    chloroquine for uncomplicated malaria in patients with chloroquine-sensitive P. falciparum or P. vivax or in
    all patients with P. malariae, P. knowlesi, or P. ovale.[64059]
  • Infants, Children, and Adolescents
    16.5 mg (10 mg base)/kg/dose [Max: 1,000 mg/dose (600 mg base/dose)] PO once, then 8.3 mg (5 mg
    base)/kg/dose [Max: 500 mg/dose (300 mg base/dose)] PO in 6 to 8 hours, then 8.3 mg (5 mg
    base)/kg/dose [Max: 500 mg/dose (300 mg base/dose)] PO once daily for 2 days.[29758] For P. vivax or
    P. ovale, give in combination with primaquine phosphate or tafenoquine. Guidelines recommend
    chloroquine for uncomplicated malaria in patients with chloroquine-sensitive P. falciparum or P. vivax or in
    all patients with P. malariae, P. knowlesi, or P. ovale.[64059]

 

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